Smurf1 antibody

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August undefined, 2024

WebIntroduction. Glial-derived tumor, or glioma, is the most common brain tumor and accounts for about 74.6% of all malignant tumors occurring in brain and central nervous system. 1 Approximately 82% of gliomas cases are diagnosed at high malignant WHO grades III and IV, with a 5-year survival rate of only 10%. 2 It is identified that radiotherapy has synergistic … Web4 Feb 2024 · CRTC2 suppresses BMP2‐induced osteoblastic differentiation via Smurf1 expression in MC3T3‐E1 cells. Kyeong-Min Kim, Wanjin Jeon, Eun-Jung Kim, W. Jang; ... The Siglec-15 neutralizing antibody effectively reduced bone resorption and stimulated bone formation in estrogen deficiency-induced osteoporosis and shows significant …

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WebAnti-SMURF1 antibody (ab94480) Datasheet SDS Reviews ( 1) Submit a question Key features and details Rabbit polyclonal to SMURF1 Suitable for: WB Reacts with: Human … Web31 Mar 2016 · C, sequential IP assay showing the RASSF1A–Smurf1–RhoA complex formation in HeLa cells. Cell lysates were precipitated with anti-RASSF1A antibody and the resulting complexes were precipitated with anti-Smurf1 antibody. D, characterization of Smurf1-binding region of RASSF1A. E, loss of RhoA-inhibiting activity of RASSF1A by … gacha ears png

SMURF1 Gene - GeneCards SMUF1 Protein SMUF1 Antibody

Web21 Feb 2024 · Smurf1 silencing restores PTEN expression that ameliorates progression of human glioblastoma and sensitizes tumor cells to mTORC1/C2 inhibitor Torin1 Article Full-text available Nov 2024 Qin Xia... WebSMURF1 interacts with receptor-regulated SMADs specific for the BMP pathway, SMAD1 and SMAD5, in order to trigger their ubiquitination and degradation and hence their … WebAntibodies Primary Antibodies and ImmunoCruz® Conjugates Synthesis and Degradation Smurf1 Antibodies Smurf1 Antibodies Santa Cruz Biotechnology, Inc. offers a broad … gacha eaten

RASSF1A Directly Antagonizes RhoA Activity through the …

Anti-SMURF1 Antibody AB10005 - EMD Millipore

WebScientific researcher with extensive experience in protein and antibody engineering. My greatest asset is being an effective leader which allows me to work with groups from multi-disciplinary backgrounds. ... Engineering protein-based inhibitors (ubiquitin variants) targeting SMURF1 and SMURF2, members of the ubiquitin proteasome system, which ... Web17 Jun 2011 · Supplemental Figure 2. Refined structures of Smurf1 WW1-WW2 complexes (A). 15-Refined NMR structures of the Smurf1 WW1-WW2 pair (residues 232-314) bound to the 208-233 segment of the Smad1 linker di-phosphorylated at S210 and S214. The structure was fitted to either the WW1 domain (left image; 0.7 Å for backbone heavy atoms of the … gacha easyWeb29 Dec 2024 · Smurf1 and RhoA could be detected in the whole cell lysates of all groups, suggesting that the whole cell lysates could be used for subsequent Co‐IP experiments. When Smurf1 antibody was used to pull down the protein complex, RhoA expression was detected in the control group (Smurf1−/RhoA−), while Ub expression was low. gacha earth

"Web8 Jun 2024 · Abstract. We aimed to investigate the role of cMet agonistic antibody (cMet Ab) in preventing kidney fibrosis during acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Additionally, we explored the effect of cMet Ab on TGF-β1/Smad pathway during the pathogenesis of kidney fibrosis. A unilateral ischemia–reperfusion injury (UIRI) … " - Smurf1 antibody

Smurf1 antibody

WebHS-152(HS152;HS 152, CAS: 2284548-09-8), HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively).Quality … WebThis SMURF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-96 amino acids from the N-terminal region of human SMURF1. Dilution : WB~~1:2000 IHC-P~~1:10~50: Format : Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium …

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Webdianova offers a wide range of primary antibodies for diverse immunoassays like IHC (FFPE), ELISA or Western Blotting. Read more! Web11 Jun 2024 · Smurf1 antibody was obtained from Invitrogen (Carlsbad, CA, USA), and ErbB2, ErbB3, Smad1 and c-Jun antibodies were purchased from Cell Signaling Technology (Danvers, MA, USA). EGFR antibody was purchased from Abcam (Cambridge, UK).

Web20 Apr 2024 · Apart from SMURF1/2, another E3 ubiquitin ligase that has been shown to influence the canonical TGF-β pathway is NEDD4-L (NEDD4-Like). Inside the nucleus, the linker region of SMAD2/3 is phosphorylated by CDK8 and CDK9 (cyclin-dependent kinase 8/9), which enhances the transcriptional activity of SMAD2/3 by favoring binding to other … Web24 Feb 2024 · DDIT3 promoted NF-κB-dependent ovarian tumor (OTU) deubiquitinase 1 (OTUD1) expression. Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination-dependent manner, ultimately inhibiting IFN-I production.

Web(sc-100616) Smurf1 Antibody (45-K) Supplier Santa Cruz Biotechnology. Host Mouse Type Primary Clonality Monoclonal (45-K) Target E3 ubiquitin-protein ligase SMURF1 (Human) UniProt Q9HCE7 - SMUF1_HUMAN. Gene SMURF1 Modification Unmodified View Product On Supplier's Website Request a Quote from Santa Cruz Biotechnology. WebSMURF1 antibody (ABIN1936804). Validated for IHC, ELISA, WB. Tested in Human, Mouse. Order online. English ... Comparison List Basket Phone: +1 877 302 8632 Fax: +1 888 205 9894 (Toll-free) E-Mail: [email protected]. Home Antibodies ELISA Kits Primary Antibodies. Monoclonal Antibodies; Polyclonal Antibodies; Recombinant Antibodies ...

WebView Rabbit Polyclonal anti-SMURF1 Antibody (H00057154-D01P). Validated Applications: WB, PLA. Validated Species: Human.

WebBriefly, the anti-SMURF1 antibody (1:500) or anti-RORγt antibody (1:1000) was immobilized for 2 h employing AminoLink Plus coupling resin. Next, the resin was further incubated … gacha easy hairWeb2 Nov 2024 · Predicted targets including Furin, a protease that cleaves pro-forms, genes encoding receptors such as Acvr2a, Bmp1a, Dies1, and Tgfbr3, molecules within the cascade like Smad5, transcriptional regulators like Ski and Zfp423 as well as Mapk3 and Smurf1 were validated by quantitative PCR. gacha eating poopWeb7 Apr 2024 · d Immunoprecipitates of FGFR2 ubiquitination in HEK293T cells transfected with Flag-Smurf1 or indicated Flag-Otub1 (WT, D88A, C91S, H265A, and A/S/A) and immunoblotted with the indicated antibodies. gacha edgy cringeWebSMURF1 antibody (ABIN781919). Validated for EIA, IF, IHC (p). Tested in Human, Mouse. Order online. English ... Comparison List Basket Phone: +1 877 302 8632 Fax: +1 888 205 9894 (Toll-free) E-Mail: [email protected]. Home Antibodies ELISA Kits Primary Antibodies. Monoclonal Antibodies; Polyclonal Antibodies; Recombinant Antibodies ... gacha eddsworldWeb18 Oct 2002 · In thebottom panel, aliquots of cell lysates were directly subjected to immunoblotting with anti-Myc antibody to confirm the expression of Smurf1(WT) or Smurf1(ΔC2). B, Smurf1(WT) but not Smurf1(ΔC2) reduced steady-state levels of the mature form of TβR-I in vivo. COS7 cells were transfected with the indicated plasmids. gacha edited handWebImmunohistochemistry-Paraffin: SMURF1 Antibody (1D7) [H00057154-M01] - Analysis of monoclonal antibody to SMURF1 on formalin-fixed paraffin-embedded human stomach. … gacha edited picsWeb19 Jan 2024 · Smurf1 Antibody (45-K) is a mouse monoclonal IgG 2a κ Smurf1 antibody, cited in 32 publications, provided at 100 µg/ml. raised against an internal portion of … gacha editing kine