WebEpidermal growth factor receptor (EGFR) is a well-known target for cancer treatment. However, the authorized anti-EGFR monoclonal antibodies generally cause several toxic effects, especially severe cutaneous toxicities as well as infusion reactions, and the clinical indications are limited. ... However, hypomagnesemia, grade 3–4 skin toxicity WebDuring the concurrent EGFR TKIs with combination WBRT phase, none of the patients required a reduction in the dose of EGFR TKIs, although skin toxicity did occur in 33.3% of patients. Other toxicities included diarrhea in 5.1% of patients, constipation in one patient, and hepatotoxicity in 7.7% of patients.
Systemic doxycycline for pre-emptive treatment of anti-EGFR …
WebWhat Patients can do: the key behavioural and prophylactic measures that can be undertaken by patients to minimise EGFRI-associated cutaneous changes. Prophylactic … WebSkin rash and diarrhea were the most frequently reported drug-related toxicities. A Phase I/II trial of 45 patients receiving cisplatin and erlotinib for R/M HNSCC demonstrated an RR of 21%, median PFS of 3.3 months, and median OS of 7.9 months. 73 There was minimal grade ≥3 toxicity. the source cairns
MASCC EGFR Inhibitor Skin Toxicity Tool (MESTT) - MASCC
WebJan 3, 2024 · The anti-EGFR-related skin toxicity is reversible after the treatment delay or interruption, and the clinical management includes both topical and systemic agents. … Web14696 Background: Epidermal growth factor receptor (EGFR) is an attractive target for anti-cancer agents, which have shown activity against various types of tumors. Skin/eye toxicity is a class adverse effect associated with anti-EGFR therapy. This project aims to determine whether skin/eye toxicity can be used as a biomarker for dose selection of anti-EGFR … WebDec 1, 2015 · EGFR inhibition is generally associated with skin rash, diarrhoea, mucositis and, less frequently, pneumonitis. VEGFR inhibition leads to hypertension, proteinuria, wound healing complications, hand-foot skin reaction (HFSR) and also some vascular complications such as arterial thromboembolism and left ventricular dysfunction. the source campbell river